Senior Principal AI/ML Scientist, Computational Imaging

Company: Amgen
Location: Washington
Posted on: January 26, 2026

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Principal AI/ML Scientist, Computational Imaging What you will do Lets do this. Lets change the world. Biomarkers and diagnostics are central to understanding how our therapeutics work and identifying patients that benefit most from these therapies. Accordingly, the Precision Medicine (PMED) function plays a critical role in advancing our drug development programs and is accountable for the development and execution of biomarkers and diagnostics strategy across our pipeline. The PMED Center for Technology and Innovation group is responsible for developing innovative biomarker assay and computational technologies that advance precision medicine objectives across therapeutic areas. We are currently seeking an AI/ML imaging expert to join our growing Computational Imaging and Digital Biomarkers team. The Senior Principal Scientist, Computational Imaging, will serve as a technical leader and hands-on scientific contributor in the development and application of advanced AI/ML methods for medical imaging, with a focus on digital pathology and/or radiology. This role is responsible for leading complex imaging AI efforts and delivering high-impact models that support biomarker discovery, patient stratification, disease characterization, and outcome prediction. The successful candidate will bring deep expertise in custom AI model development, particularly in leveraging public and proprietary foundation models to develop novel segmentation, classification, and predictive models. This role operates in a matrixed environment, partnering closely with translational pathology, clinical imaging, clinical biomarkers, and computational biologist stakeholders, while mentoring junior scientists and influencing external collaborations. This position will report directly to the Executive Director of Computational Imaging and Digital Biomarkers. In this vital role you will successfully partner with cross-functional stakeholders to drive development and implementation of imaging-based biomarkers and diagnostics. Technical Leadership & Execution Lead the design, development, training, and validation of AI/ML models for digital pathology and/or radiology applications. Define technical direction for custom AI/ML model development, including architecture selection, training paradigms, validation strategies, and performance benchmarks. Develop custom deep learning architectures and workflows for segmentation, classification, representation learning, and prediction tasks. Leverage and adapt foundation models (e.g., vision transformers, multimodal and self-supervised models), including fine-tuning and domain adaptation using proprietary datasets. Data Science & Modeling Excellence Extract insights from large-scale imaging datasets, including whole-slide images and radiology modalities (CT, MRI, PET). Apply advanced computer vision and machine learning methods, including CNNs, U-Net variants, Vision Transformers, diffusion-based or representation-learning models. Define appropriate evaluation strategies and ensure analytical rigor, reproducibility, and scientific credibility. Integrate imaging data with clinical, molecular, or spatial-omics data where relevant. Balance innovation with practicality, ensuring solutions are scalable, interpretable, and fit-for-purpose. Cross-Functional Collaboration Work closely with pathologists, radiologists, clinicians, and translational scientists to translate scientific questions into computational imaging solutions. Clearly communicate modeling approaches, assumptions, results, and limitations to technical and non-technical stakeholders. Contribute to shaping project-level research questions and study designs involving imaging data. Support external collaborations through technical input and scientific exchange as needed. Scientific Contribution & Mentorship Contribute to the organizations scientific visibility through publications, presentations, and internal knowledge sharing. Provide informal mentorship and technical guidance to junior scientists and collaborators. Stay current with advances in AI, computer vision, and medical imaging to continuously elevate technical approaches. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications. Basic Qualifications: Doctorate degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 3 years of related experience Or Masters degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 6 years of related industry experience Or Bachelors degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 8 years of related industry experience Preferred Qualifications: Demonstrated deep technical expertise in developing custom AI/ML models for medical imaging. Strong experience in digital pathology and/or radiology, including whole-slide images and/or modalities such as CT, MRI, or PET. Expertise in foundation model usage, including pre-training, fine-tuning, and domain adaptation for imaging-based tasks. Advanced knowledge of modern computer vision and ML techniques, including: CNNs, U-Netbased architectures, Vision Transformers Self-supervised, weakly supervised, and few-shot learning Multimodal and representation learning approaches Proficiency in Python and deep learning frameworks such as PyTorch and/or TensorFlow. Demonstrated ability to communicate complex technical concepts clearly and influence scientific decision-making. Strong record of scientific contributions (e.g., publications, patents, deployed models, or platform capabilities). Demonstrated evidence of setting and implementing technical or scientific strategies for complex AI/ML or computational imaging initiatives, including defining problem statements, selecting modeling approaches, and driving execution to measurable scientific or translational outcomes. Strong publication record in AI/ML, with particular emphasis on applications to drug development, biomarker discovery, patient stratification, or translational research; contributions to high-impact journals or top-tier AI/medical imaging conferences strongly preferred. Experience working with integrated imaging, clinical, and molecular datasets. Familiarity with MLOps, scalable training, and model lifecycle management. Experience with cloud or HPC environments (e.g., AWS, Azure, GCP, SLURM), containerization, and distributed training. Prior experience leading significant components of cross-functional or external collaboration What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation

Keywords: Amgen, Harrisburg , Senior Principal AI/ML Scientist, Computational Imaging, Science, Research & Development , Washington, Pennsylvania